Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata

Anthony R Carroll; Sylvia Urban; Jasmine Lamb; Roger Moni; Gordon P Guymer; Paul I Forster; Ronald J Quinn

doi:10.1021/np0706567

Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata

J Nat Prod. 2008 May;71(5):881-3. doi: 10.1021/np0706567. Epub 2008 Apr 16.

Authors

Anthony R Carroll¹, Sylvia Urban, Jasmine Lamb, Roger Moni, Gordon P Guymer, Paul I Forster, Ronald J Quinn

Affiliation

¹ Eskitis Institute, Griffith University, Brisbane, Queensland, Australia.

PMID: 18412395
DOI: 10.1021/np0706567

Abstract

High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC 50 values of 23 and 19 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Flowers / chemistry
Myrtaceae / chemistry*
Nuclear Magnetic Resonance, Biomolecular
Phloroglucinol / analogs & derivatives*
Phloroglucinol / chemistry
Phloroglucinol / isolation & purification*
Phloroglucinol / pharmacology*
Plants, Medicinal / chemistry*
Queensland
Rats
Receptors, Thyrotropin-Releasing Hormone / agonists*

Substances

Receptors, Thyrotropin-Releasing Hormone
corymbone A
corymbone B
Phloroglucinol